Pharmaceutical Sciences

教育

• Ph.D., Biological Sciences, 部门 of 生物学, University of Pennsylvania, Philadelphia, PA
• B.S., Biological Sciences, 部门 of 生物学, State University of New York at Stony Brook, NY

COURSES TAUGHT AT ACPHS

• PSC-321 and PSC-322: Physiology and Pathophysiology
• PSC-315: Immunology

RESEARCH  INTERESTS

• Mechanism of action of cancer preventives and therapeutics.
• Liver toxicity of 3,4-methylenedioxymethamphetamine (MDMA, ecstasy) and alcohol.  
• Pharmacogenomics (implementation in the USA healthcare system).
  • Detailing the molecular effects of berry extracts (aronia and seabuckthorn) and other natural compounds on cancer cell growth and death.
  • Elucidation of the mechanism of drug interaction between MDMA and alcohol.

奖助金

• Characterization of the anticancer activities of sea buckthorn (Hippophae rhamnoides) berry extracts, 病死率&D grant, Notre Dame of Maryland University, Insong James Lee, (PI) 6,000.00 (2015).
• Anticancer effects of claudin protein repression by indole-3-carbinol, NIH EARDA grant # HD046353-04, $10,000. Insong James Lee (PI) (2009). 
• Regulation of CYP2B6 in Human Liver, National Institutes of Health: Grant # 2R01DK061652-05A2, $ 1,025,000.00.  Wang HB, 李IJ, Ross D (2007-2011).
• Inhibition of the breast cancer marker MUC1 by the chemo-preventative, 仅仅, 苏珊·G. Komen Breast Cancer Foundation: Grant # BCTR04025132, $ 249,555.00. 李IJ (PI) (2004).

奖

• Teacher of the year 2014 

PROFESSIONAL ORGANIZATIONS

• American Association for the Advancement of Science (AAAS)
• American Association for Cancer 研究 (AACR)
• American Association of Colleges of Pharmacy (AACP)
• International Society for the Study of Xenobiotics (ISSX)
• The Association of Biochemistry Educator (ABE)
• The Rho Chi Honor Society (RHO)

出版物

• Accessibility and coverage of pharmacogenomics testing by major health insurance companies.  Park S, Thigpen J, 李IJ. (manuscript in preparation).
• 仅仅 increases the integrity of tight junctions and represses the level of tight junction proteins, claudin-3 and -4 in cancer cells.  Kim SK, 哈桑,他, 爱丁顿ND, 李IJ. (manuscript in preparation).
• Increased oxidative-modifications of cytosolic proteins in 3,4- methylenedioxymethamphetamine (MDMA, ecstasy)-exposed rat liver.  Upreti VV, Moon K-H, Yu L-R, 李IJ, 爱丁顿ND, Ye X, Veenstra TD, Song BJ.  Proteomics 2011 11(2), 202-211. 
• Mechanisms of MDMA (ecstasy)-induced oxidative stress, mitochondrial dysfunction, and organ damage.  Song B J, Moon KH, Upreti VV, 爱丁顿ND, 李IJ.  2010. Current Pharmaceutical Biotechnology 2011, 11(5), 434-443.
• Regulation of gene expression in brain tissues of rats repeatedly treated by the highly abused opioid agonist, oxycodone: microarray profiling and gene mapping analysis.  哈桑,他, Myers AL, 李IJ, Chen H, Coop A, 爱丁顿ND.  药物处置. 2010 Jan;38(1):157-67.
• Estradiol and progesterone-mediated regulation of P-gp in P-gp overexpressing cells (NCI-ADR-RES) and 胎盘l cells (JAR).  Coles LD, 李IJ, Voulalas PJ, 爱丁顿ND.  摩尔制药. 2009 Nov-Dec;6(6):1816-25.
• Distribution of saquinavir, 美沙酮, and buprenorphine in maternal brain, 胎盘, and fetus during two different gestational stages of pregnancy in mice. Coles LD, 李IJ, 哈桑,他, 爱丁顿ND.  [J]医药科学. 2009 Aug;98(8):2832-46.
• NMR metabolomic analysis of caco-2 cell differentiation. 李IJ, Hom K, Bai G, Shapiro M.    J蛋白质组学. 2009 Aug;8(8):4104-8.
• Drug interaction between ethanol and 3,4-methylenedioxymethamphetamine ("ecstasy"). Upreti VV, 爱丁顿ND, Moon KH, Song BJ, 李IJ.  Toxicol列托人. 2009 Jul 24;188(2):167-72. 
• Evaluation of the transport, in vitro metabolism and pharmacokinetics of Salvinorin A, a potent hallucinogen. Teksin z, 李IJ, Nemieboka神经网络, 奥斯曼AA, Upreti VV, 哈桑,他, Syed党卫军, Prisinzano TE, 爱丁顿ND.  Eur J Pharm Biopharm. 2009 Jun;72(2):471-7.

ACPHS委员会

• College Curriculum Committee 
• Academic Standing Appeals Committee